Abstract

ULATE MONTERO, Guido  and  ULATE CAMPOS, Adriana. El calcio en los miocitos cardíacos y su papel en las miocardiopatías.. Rev. costarric. cardiol [online]. 2006, vol.8, n.1, pp.19-25. ISSN 1409-4142.

The rol played by calcium in cardiomyocytes includes a great number of functions like the excitation-contraction coupling as well as a second messenger in diverse signaling pathways. Some of these pathways are activated in processes that affect the cardiac tissue integrity and also participate in cell growth and apoptosis, determining the poor prognosis that characterize the majority of the cardiomyopathies. In this review,the mechanisms inside the cardiomyocytes in which participates calcium and the pathophysiological changes observed in some cardiac diseases like arrhythmogenic right ventricular cardiomyopathy, catecholaminergic polymorphic ventricular tachycardia, idiopathic dilated cardiomyopathy, and others, are described. The action mechanism of positive inotropic drugs that act as sarcomere myofilaments sensitizers is also reviewed.

Keywords : Calcium; cardiomyocytes; cardiomyopathies; levosimendan; heart disease.

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