Resumen

GARCIA, Jorge. La preincubación de macrófagos alveolares de rata con vitamina C o E atenúa el daño a la membrana plasmática causado por exposición a ozono. Rev. costarric. cienc. méd [online]. 2001, vol.22, n.3-4, pp.151-160. ISSN 0253-2948.

The damaging effects of a 60 minute ozone exposure (0,594 ppm) on the cell membrane of rat alveolar macrophages was assessed by measuring specific release of⁵¹Cr label from the cells. Preincubation of the macrophages in the presence of vitamin C (sodium ascorbate) or vitamin E (DL  tocoferol) prior to ozone exposure significantly diminished ⁵¹Cr release. The protective effect of vitamin E was dose dependent. A proposal accounting for the protective effect of vitamins E and C on the cell membrane is presented, and our findings are discussed in relation to recent reports showing that antioxidant supplementation contributes to preserve pulmonary function in ozone-exposed normal and asthmatic volunteers.