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Revista Costarricense de Ciencias Médicas

Print version ISSN 0253-2948

Abstract

GARCIA, Jorge. La preincubación de macrófagos alveolares de rata con vitamina C o E atenúa el daño a la membrana plasmática causado por exposición a ozono. Rev. costarric. cienc. méd [online]. 2001, vol.22, n.3-4, pp.151-160. ISSN 0253-2948.

The damaging effects of a 60 minute ozone exposure (0,594 ppm) on the cell membrane of rat alveolar macrophages was assessed by measuring specific release of51Cr label from the cells. Preincubation of the macrophages in the presence of vitamin C (sodium ascorbate) or vitamin E (DL  tocoferol) prior to ozone exposure significantly diminished 51Cr release. The protective effect of vitamin E was dose dependent. A proposal accounting for the protective effect of vitamins E and C on the cell membrane is presented, and our findings are discussed in relation to recent reports showing that antioxidant supplementation contributes to preserve pulmonary function in ozone-exposed normal and asthmatic volunteers.

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