Resumen

SAENZ-CAMPOS, Desirée; PARRA B., Pilar  y  BARBANOJ R., Manel J.. Alprazolam: análisis de posibles diferencias farmacocinéticas debidas al sexo. Rev. costarric. cienc. méd [online]. 1997, vol.18, n.3, pp.35-41. ISSN 0253-2948.

To evaluate the possible influence of gender in the pharmacokinetic behavior of benzodiazepines, a single oral dose of alprazolam 1 mg was administered to 8 men and 8 women, all healthy subjects. Samples for plasmatic concentrations (Cp) were extracted at the following times: 0, 0,5, 1, 1,5, 2, 4, 6, 7, 9, 10, 12, 24 y 48 hours. The maximum plasma drug concentration (C_max) was 11,73±2,55 ng/mL and the time to reach peax concentration (t_max) varied betwen + 1 y +1,5 hs. The elimination half-life (t_½) was 14,21 ±5,72 h and the area under the concentration-time curve 0 to 48 hs (AUC_0-48) reached a magnitude of 135,16±62,89 ng/mL-; h. Similar profiles of Cp were found and kinetic parameters were equivalent in both sexes. We also found a good tolerance to the drug in all subjects. In this assay, we conclude that the results do not suggest kinetic diferences by sex after ALZ ; however, other assays like this help to describe whether kinetics differences really can be gender related.

Palabras clave : Alprazolam; sex-kinetic behavior; healthy subjects.