Abstract

BOLANOS-PALMIERI, Patricia; CHAVARRIA-SOLEY, Gabriela; CONTRERAS, Javier  and  RAVENTOS, Henriette. A quarter century of genetic research on neuropsychiatric disorders in Costa Rica. Rev. biol. trop [online]. 2019, vol.67, n.2, pp.1-25. ISSN 0034-7744.  http://dx.doi.org/10.15517/rbt.v67i2supl.37188.

In Costa Rica, the study of the genetic basis of neuropsychiatric disorders started more than 25 years ago. During this time, different research efforts have focused on several disorders: schizophrenia, bipolar disorder, Alzheimer’s disease, obsessive-compulsive disorder, attention deficit/hyperactivity disorder, and Tourette syndrome. The studies have had a wide scope regarding design (linkage/association), sample used (families/sib pairs/trios), genome coverage (candidate gene studies/genome-wide scans), and phenotype definition (diagnostic category/syndromic classification/endophenotype). Here we present a summary of the main genomic findings of these multidisciplinary studies, and discuss the importance, lessons, and challenges of genetic research of complex psychiatric disorders.

Keywords : psychiatry; brain; gene mapping; phenotype; endophenotype; gene.

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