SciELO - Scientific Electronic Library Online

 
vol.47 issue3Relaciones tróficas de cinco peces costeros comunes en el área submareal del norte de Chile (20°11'-20°20'S)Tamaño gonadal de machos de Chaetodipus arenarius (Rodentia: Heteromyidae) durante un ciclo reproductivo en Baja California Sur, México author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Revista de Biología Tropical

On-line version ISSN 0034-7744

Abstract

CASTRO, Oscar et al. Neutralización del efecto hemorrágico inducido por veneno de Bothrops asper (Serpentes: Viperidae) por extractos de plantas tropicales. Rev. biol. trop [online]. 1999, vol.47, n.3, pp. 605-616. ISSN 0034-7744.

Organic extracts representing 48 species included in 30 families of Costa Rican tropical plants were evaluated for their ability to neutralize hemorrhagic activity induced by the venom of the snake Bothrops asper. A bioassay in mice was used, based on intradermal injection of either venom or venom-extract mixtures followed by the measurement of hemorrhagic areas. Total inhibition of hemorrhage was observed with the ethanolic, ethyl acetate and aquous extracts of Bursera simaruba, Clusia torresii, C. palmana, Croton draco, Persea americana, Phoebe brenesii, Pimenta dioica, Sapindus saponaria, Smilax cuculmeca and Virola koschnyi. Chemical analysis of these extracts identified catequines, flavones, anthocyanines and condensated tannins, which may be responsible for the inhibitory effect observed, probably owing to the chelation of the zinc required for the catalytic activity of venom’s hemorrhagic metalloproteinases.

Keywords : Anti-hemorrhagic plants; anti-venom plants; snake venom; flavonoids; tannins.

        · abstract in Spanish     · text in Spanish

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License