Abstract

CHINCHILLA, Misael et al. An in vivo model to study the anti-malaric capacity of plant extracts. Rev. biol. trop [online]. 1998, vol.46, n.1, pp.35-39. ISSN 0034-7744.

An in vivo model to study the antimalaric effect of plant extracts is described. White mice (25-30g body weight) are treated subcutaneously with 0.6ml of the diluted extract starting seven days before P. berghei infection; treatment continues until death or for 30 days. Simultaneously 0.2ml of the extract are applied per os starting three days before infection. In a test of the model, treated and non-treated animals differed in body weight, survival time, haematocrite, parasitemia development, and spleen or liver weight of recent dead or killed mice.

Keywords : Malaria; Plasmodium berghei; treatment; plants.