Resumo

BOZA-CORDERO, Ricardo. HIV/AIDS and epigenetic. Acta méd. costarric [online]. 2023, vol.65, n.1, pp.3-11. ISSN 0001-6002.  http://dx.doi.org/10.51481/amc.v65i1.1247.

Since 1981, over 75 million people have been infected with human immunodeficiency virus. The survival rate of patients with this infection has dramatically increased with the use of antiretroviral therapy, and this therapy significantly reduced the incidence of AIDS defining events. Despite recent progress, neither a cure nor a preventive vaccine against human immunodeficiency virus infection is likely to become available soon. Epigenetics is defined as the study of chemical modifications of intrinsic and extrinsic factors of the genetic code regulating gene expression. Three types of epigenetic markers have been found: DNA methylation, post-translational histone modifications, and non-coding RNA (ncRNA). In this review, we analyzed recent research about the relation between epigenetic mechanisms, the persistence of HIV in host cells, the chronic inflammatory response evoked, the cardiovascular diseases associated and premature aging in this population.

Palavras-chave : HIV; AIDS; epigenetics; genes.

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