Resumo

CENTENO-URENA, Yadel  e  ULLOA-MORALES, Alejandro. Immune activation by advanced glycation endproducts. Acta méd. costarric [online]. 2021, vol.63, n.4, pp.199-209. ISSN 0001-6002.  http://dx.doi.org/10.51481/amc.v63i4.1212.

To review recent advances in the biology of advanced glycation endproducts and its role in diverse pathologies of high relevance for public health, a survey of the literature from the years 2000 to 2021 was performed in PubMed (NCBI) using the key words “advanced glycation endproducts”. It has been demonstrated that the receptor for advanced glyca- tion endproducts (RAGE) induces a sustained activation of the pro-inflammatory tran- scription factor NF-kB and suppresses a series of endogenous self-regulating functions. This affects negatively on a wide variety of pathological conditions such as diabetes, au- toimmunity, neurodegeneration and infectious disease. Tissular accumulation of AGEs is linked to chronic inflammation and cellular dysfunction and constitutes a promising target for the design of treatments focused on this signaling pathway. Multiple clinical trials are currently underway to define its usefulness as a marker of pulmonary lesions in COVID-19.

Palavras-chave : diabetes; neurodegeneration; advanced glycation; receptor for advanced glycation end products; COVID-19.

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