SciELO - Scientific Electronic Library Online

 
vol.63 issue4Microbiology of diabetic foot infections author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • Have no similar articlesSimilars in SciELO

Share


Acta Médica Costarricense

On-line version ISSN 0001-6002Print version ISSN 0001-6012

Abstract

CENTENO-URENA, Yadel  and  ULLOA-MORALES, Alejandro. Immune activation by advanced glycation endproducts. Acta méd. costarric [online]. 2021, vol.63, n.4, pp.199-209. ISSN 0001-6002.  http://dx.doi.org/10.51481/amc.v63i4.1212.

To review recent advances in the biology of advanced glycation endproducts and its role in diverse pathologies of high relevance for public health, a survey of the literature from the years 2000 to 2021 was performed in PubMed (NCBI) using the key words “advanced glycation endproducts”. It has been demonstrated that the receptor for advanced glyca- tion endproducts (RAGE) induces a sustained activation of the pro-inflammatory tran- scription factor NF-kB and suppresses a series of endogenous self-regulating functions. This affects negatively on a wide variety of pathological conditions such as diabetes, au- toimmunity, neurodegeneration and infectious disease. Tissular accumulation of AGEs is linked to chronic inflammation and cellular dysfunction and constitutes a promising target for the design of treatments focused on this signaling pathway. Multiple clinical trials are currently underway to define its usefulness as a marker of pulmonary lesions in COVID-19.

Keywords : diabetes; neurodegeneration; advanced glycation; receptor for advanced glycation end products; COVID-19.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )