SciELO - Scientific Electronic Library Online

 
vol.62 issue4Effect of pulmonary rehabilitation on respiratory function and exercise capacity in people with chronic lung diseaseUremic neuropathy reversion after kidney transplantation author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • Have no similar articlesSimilars in SciELO

Share


Acta Médica Costarricense

On-line version ISSN 0001-6002Print version ISSN 0001-6012

Abstract

RAMIREZ-QUESADA, Wagner Enrique; MADRIGAL-BORLOZ, Marianella; BARAHONA-GARCIA, Ricardo  and  HEVIA-URRUTIA, Francisco. Sustained virological response in patients with chronic hepatitis C treated with direct acting antivirals, a retrospective study from Costa Rica. Acta méd. costarric [online]. 2020, vol.62, n.4, pp.187-195. ISSN 0001-6002.

Introduction:

Costa Rica has a public healthcare system that made possible the detection of hepatitis C (HCV) infected patients and offer them treatment with last-generation direct-acting antivirals (DAA). Nonetheless, there has not been any published studies that evaluate the response of the Costa Rican population to these drugs.

Aim:

To describe the clinical effectiveness of direct acting antiviral treatment in a cohort treated in the Social Security Care from Costa Rica (CCSS).

Materials and Methods:

Retrospective review of clinical records of all patients who were treated with: sofosbuvir/ledipasvir, sofosbuvir/velpatasvir and ombitasvir/paritaprevir/ritonavir/dasabuvir in three national adult hospitals from between 2017-2018. Epidemiological, clinical and laboratory data were collected, and pre- and post- treatment results were compared.

Results:

139 patients were recruited, 22 were excluded because they did not fulfill the inclusión criteria. The analysis was made with 117 patients; from which 101 had their viremia documented in their records for the determination of sustained virological response (SVR). The majority of patients were Costa Ricans born between 1945-1965, whose risk factors for hepatitis C were not documented, with a non-cirrhotic, genotype 1b infection. Overall SVR was 98%. There was not a significant difference of response between cirrhotic (94%) and non-cirrhotic population (100%).

There was a significant reduction (p< 0,01) in:

Aspartate Aminotranferase to Platelet Ratio Index (APRI), the score of the Model for End-Stage Liver Disease (MELD), Alanine Aminotransferase (ALT) and total bilirubin in patients treated with DAA.

Conclusion:

The direct acting antivirals were effective in population treated in our country, with SVR similar to those reported in real life studies from other regions of the world.

Keywords : hepatitis C; antivirales; Costa Rica; sustained viral virologic response.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )