Resumo

MOYA-ZELEDON, Diego  e  MADRIGAL-SANCHEZ, Juan José. Angiotensin Converting Enzyme Insertion/Deletion Polymorphism and its Association with Complications in Patients with type 2 Diabetes Mellitus. Acta méd. costarric [online]. 2012, vol.54, n.2, pp.102-108. ISSN 0001-6002.

Background: Diabetes mellitus is a disease with serious repercussions on the Costa Rican population and it predisposes patients to diverse complications. The exact origin of these complications is not known; it has been suggested that certain polymorphisms are strongly associated with the appearance of some of them.   Aim: To determine if there is a relation between complications from diabetes and the insertion/deletion polymorphism of the angiotensin converting enzyme.   Methods: This investigation included 225 subjects. 109 were cases and 116 control subjects. A blood sample was taken from each participant and fibrinogen levels were measured; also, using a polymerase chain reaction of the intron 16 of the angiotensin converting enzyme gene, the insertion/deletion mutation of the angiotensin converting enzyme was studied. Then, the results were compared to the presence of diabetes or its complications.   Results: A greater number of controls were found to have insertion/deletion polymorphism, however this was not considered statistically significant. In the case group, none of the polymorphisms showed a dominant behavior. D/D was associated with high levels of fibrinogen.   Conclusion: No strong association was found between the polymorphisms of the angiotensin converting enzyme and suffering from Diabetes mellitus type 2 in the studied population. Using a logistic regression analysis, it was determined that the polymorphism D/D is significant regarding the predisposition to develop diabetes, but it explains only 3,58% of this variable, therefore there are variables that have a greater significance. Yet, elevated levels of fibrinogen are related with the polymorphism D/D. It can be established that in the studied population there is no relation between the polymorphisms of the angiotensin converting enzyme and the emergence of complications from diabetes.

Palavras-chave : Diabetes mellitus; angiotensin converting enzyme; polymorphism; PCR.

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