Abstract

RAMOS-ESQUIVEL, Allan  and  FLORES-BONICHE, Alejandro. Farmacogenomics Era: The Clopidogrel Example. Acta méd. costarric [online]. 2012, vol.54, n.1, pp.15-22. ISSN 0001-6002.

Pharmacology is a branch of the medicine with growing new techniques in sequencing and genetic epidemiology. Recently, a large amount of scientific studies has brought up a question mark as for the possibility to provide an individualized therapy, based on the genetic grounds of each individual. This topic arises a particular interest, when the genetic component modifies the pharmacologic response to a widely prescribed drug, such as clopidogrel, mainly used in Acute Coronary Syndrome cases and Percutaneous Coronary Interventions. This review discusses aspects related to the mechanisms of action of clopidogrel, and the way these processes can be affected by genetic variations, altering the clinical outcomes of patients receiving this drug.

Keywords : Clopidogrel; farmacogenomics; pharmacology; genetic.

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