Abstract

AGUILAR-MORALES, Lara; SOLEY-GUTIERREZ, Carolina  and  ARGUEDAS-MOHS, Adriano. Principios farmacocinéticos y farmacodinámicos en el tratamiento de niños con otitis media. Acta méd. costarric [online]. 2006, vol.48, n.3, pp.113-118. ISSN 0001-6002.

Because acute respiratory infections and particularly acute otitis media (AOM), are the most common cause of antimicrobial prescription in pediatric patients, it is important to optimize antimicrobial therapies. It is essential that before prescribing an antimicrobial agent, the AOM diagnosis is well established and the local microbiological pattern is known. The present review incorporates novel concepts for the selection of the antimicrobial therapy in children with AOM taking into account pharmacokinetic and pharmacodynamic principles applied to microbiologycal concepts. These new concepts have revolutionized the treatment of diverse infectious diseases in pediatric patients and particularly in the treatment of children with otitis media.

Keywords : pharmacokinetic; pharmacodynamic; otitis media.