Resumen

SAENZ-RENAULD, German F. Hemoglobinas anormales. Acta méd. costarric [online]. 2005, vol.47, n.4, pp.173-179. ISSN 0001-6002.

The frequecy of the commonest costarican Hgb varieties can the tracked to Africa. Hbg S and C, are genetic markers, that maintain a balanced polymorphism against malaria at the countries of origen. Among the caucasian population structural mutations of Hgb are unusual and it is felt that our indians exhibited no alteration at their Hgb loci. The real public health problem of hederitary Hgb diseases, specially drepanocytosis, can be seen through a brief anthropological, clinical, diagnostic, genetic, and epidemiological review. The problem of G6PD deficiency in blacks and negroids is alluded to.

Palabras clave : Hemopoiesis; globin genes; abnormal hemoglobines; malaria; hereditary animia; sickle cell syndromes; sickle cell gene haplotipes.