Abstract

GARCIA-TORRES, Viviana; VARGAS-MARIN, Jorge  and  GARCIA-SANCHO, Hernán. Respuesta a los diferentes esquemas terapéuticos empleados en el tratamiento de la nefropatía lúpica. Acta méd. costarric [online]. 2005, vol.47, n.3, pp.126-132. ISSN 0001-6002.

AIM: Lupus nephritis is considered the prototype for immune complex- mediated glomerulonephritis. There is a great variety of clinical manifestations and histologyc changes associated with this disorder. Patients are at high risk of progressive decline of renal function as a result of organ injury secondary to the interaction of immune and chronic sclerosing mechanisms. Monitoring activity parameters, renal protein excretion, and urinary sediment, make it easier for the recognition of the prognosis and treatment of this disease. This investigation was made in order to compare the response of patients diagnosed with lupus nephritis to the different therapeutic regimens used for the treatment of this entity at the Rheumatology Service of the Hospital Mexico. Methods: A retrospective, cross sectional study was made, of the clinical files of patients diagnosed with lupus nephritis at seen the Rheumatology Service of the Hospital Mexico from 1990 to 1999. A comparison was made of the response to the different therapeutic regimens used for treatment in each patient. Results: There were 65 patients diagnosed with lupus nephritis, with a female/male ratio was of 5/1. The majority of the group was from 20 to 40 years. The most common hystologic finding on renal biopses was type IV lupus nephritis. From all the therapeutic regimens, the one that included prednisone and cyclophosphamide was more frequently used than any other (52,3%). The use of this regimen showed improvement in all of the analyzed clinical parameters. Cyclophosphamide was the drug that produced more adverse effects. The use of prednisone-cyclophosphamide demonstrated major efficacy in the treatment of patients with lupus nephritis

Keywords : Lupus Eritematoso Sistémico; Glomerulonefritis Lúpica; tratamiento; prednisona; azatioprina; ciclofosfamida; Systemic Lupus Erythematosus; Lupus Nephritis; treatment; Prednisone; azatioprina; cyclophosphamide.