Resumo

BEHM-LOPEZ, Bertrand  e  SALAS-HERRERA, lsaías. El papel de los anti-inflamatorios no esteroideos en la producción de fasceítis necrotizante. Acta méd. costarric [online]. 2002, vol.44, n.1, pp.5-9. ISSN 0001-6002.

Necrotizing fasceiitis, as a severe group A streptococcus infection generally originating from localizad skin infections or disruptions has increased worldwide in recent years. Early diagnosis is often difficult due to the appearance of characteristic soft tissue changes only late in the course of the disease. The medical literatura was analized to determine a possible association between non-setroidal antiinflammatory drugs and necrotizing fasceiitis and possible factors involved in necrotizing fasceiitis. Sample sizes of the clinical studies reviewed were small, non-randomized, without control groups. Thus, no clinical studies showed scientific evidence of a cause and effect relationship between non-setroidal anti-inflammatory drugs and necrotizing fasceiitis, regardless of the route of administration. Further well-designed clinical trials should be carried out to determine if there is a possible association between nonsetroidal anti-inflan-irnatory drugs and necrotizing fasceitis.

Palavras-chave : fasceítis necrotizante; anti-inflamatorios no esteroideos; infección; inmunosupresión.